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KMID : 1035620150030060446
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Allergy Asthma & Respiratory Disease
2015 Volume.3 No. 6 p.446 ~ p.448
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Pravastatin-induced Stevens-Johnson syndrome
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유지은:Yu Ji-Eun
최영환:Choi Young-Hwan/정지웅:Jeong Ji-ung/조규만:Cho Kyu-Man/고영일:Koh Young-Il
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Abstract
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Stevens-Johnson syndrome (SJS) manifests with severe cutaneous reactions, most commonly triggered by medications, which are characterized by fever and mucocutaneous lesions leading to necrosis and sloughing of the epidermis. To our knowledge, pravastatin-induced SJS has not yet been reported. Here, we describe a case of SJS due to pravastatin, which was diagnosed by a patch test. A 70-year-old woman presented with maculopapular skin rashes, which developed 2 weeks after medication of bisoprolol, amlodipine, pravastatin, spironolactone, and indobufene for cardiac problems. Various bullous-erosive mucocutaneous lesions occupied less than 10% of the total body surface area. Painful oropharyngeal mucous membrane lesions were observed. The vermilion border of the lips became denuded and developed serosanguinous crusts. With the drug withdrawal and the use of systemic corticosteroids, her manifestations resolved. Drug patch tests with bisoprolol, amlodipine, pravastatin, spironolactone, and indobufene were performed, resulting in a positive reaction to pravastatin, but not to the other drugs. To the best of our knowledge, this is the first case of pravastatin-induced SJS.
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KEYWORD
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Stevens-Johnson syndrome, Pravastatin, Patch test
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